產(chǎn)品介紹 品名 Monoclonal Antibody to Human C4 (C4c) 貨號 A211 規(guī)格 100 μL 同種型 IgG1K 蛋白質(zhì)濃度 > 1.0 mg/mL 緩沖液 Borate Buffered Saline (pH 8.4 ± 0.2) 物種交叉反應 Human, baboon. 儲存 ≤ 30 Days 2-8?C > 30 Days ≤ –20?C 背景 Activation of the classical complement pathway begins with the binding of an activating substance (e.g. immune complex) to the C1q molecule of C1.This, in turn, activates the C1r(2)C1s(2) sub-units,resulting in cleavage of C4 to C4b near the amino terminus of the gamma chain releasing C4a in the process. The short-lived C4b molecule can bind covalently to membranes or other surfaces via either an amide or ester bond. This is an inefficient process that is limited to the immediate vicinity of the C1 complex. C4b then takes part in the classical convertase enzyme. Because of the short life of the C4b molecule much of the C4d is free and circulates in serum 描述 A murine monoclonal antibody to an epitope in the C4c domain of C4. This monoclonal antibody was raised against purified human C. It is specific for an antigen expressed on the C4c domain of C4 and therefore reactive to C4 and all C4c-containing fragments of C4. Quidel's C4 (C4c) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry. 應用 Because specific techniques differ from lab to lab, the provided information should be used as a guideline only. 參考文獻 1、Pascher, A. et al. Immunopathological observations after xenogeneic liver perfusions using donor pigs transgenic for human decayaccelerating factor 1,2. Transplantation 64:384-391 (1997). 2、Barilla-LaBarca, M.L. et al. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol 168:6298-6304 (2002).
產(chǎn)品介紹
Monoclonal Antibody to Human C4 (C4c)
A211
100 μL
IgG1K
> 1.0 mg/mL
Borate Buffered Saline (pH 8.4 ± 0.2)
Human, baboon.
≤ 30 Days 2-8?C
> 30 Days ≤ –20?C
Activation of the classical complement pathway begins with the binding of an activating substance (e.g. immune complex) to the C1q molecule of C1.This, in turn, activates the C1r(2)C1s(2) sub-units,resulting in cleavage of C4 to C4b near the amino terminus of the gamma chain releasing C4a in the process. The short-lived C4b molecule can bind covalently to membranes or other surfaces via either an amide or ester bond. This is an inefficient process that is limited to the immediate vicinity of the C1 complex. C4b then takes part in the classical convertase enzyme. Because of the short life of the C4b molecule much of the C4d is free and circulates in serum
A murine monoclonal antibody to an epitope in the C4c domain of C4.
This monoclonal antibody was raised against purified human C. It is specific for an antigen expressed on the C4c domain of C4 and therefore reactive to C4 and all C4c-containing fragments of C4.
Quidel's C4 (C4c) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry.
Because specific techniques differ from lab to lab, the provided information should be used as a guideline only.
1、Pascher, A. et al. Immunopathological observations after xenogeneic liver perfusions using donor pigs transgenic for human decayaccelerating factor 1,2. Transplantation 64:384-391 (1997).
2、Barilla-LaBarca, M.L. et al. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol 168:6298-6304 (2002).
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