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A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1 and TNF (IC= 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 M) completely or partially inhibited platelet agonist induced p38 activation (IC= 4 to 20 nM).

Additional Information

Synonyms	2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Product #	V-2481
CAS #	479543-46-9
Chemical Name	2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Formula	C19H12F4N4O2
MW	404.32
Appearance	White soild
Purity	99% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Inflammatory Diseases
Use	VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis

Additional Information

MDL Number	MFCD11616590
ChemACX	X1829255-4
InChI	InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
SMILES	C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F