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A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor . The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).

Additional Information

Synonyms	Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II
Product #	V-1080
CAS #	288144-20-7
Chemical Name	(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
Formula	C17H15BrN2O
MW	343.2
Appearance	Brown Solid
Purity	95%
Solubility	Soluble in DMSO
Storage Temp	-20°C

Additional Information

MDL Number	MFCD03453583
InChI	InChI=1S/C17H15BrN2O/c18-11-5-6-13-14(17(21)20-16(13)8-11)9-12-7-10-3-1-2-4-15(10)19-12/h5-9,19H,1-4H2,(H,20,21)/b14-9-
SMILES	c1cc\2c(cc1Br)NC(=O)/C2=C\c3cc4c([nH]3)CCCC4